By　means　of　the　in　situ　ligand　formation　strategy　and　hard　soft　acid　base　(HSAB)　theory,　two　types　of　independent　In(COO)(4)　and　Cu6S6　clusters　were　rationally　embedded　into　the　heterometallic　metal　organic　framework　(HMOF)　{[(CH3)(2)NH2]InCu4L4.xS}(n)　(BUT-52).　BUT-52　exhibits　a　three-dimensional　(3D)　anionic　framework　structure　and　has　sulfur　decorating　the　dumbbell-shaped　cages　with　the　external　edges　of　24　and　14　A　by　the　internal　edges.　Remarkably,　because　of　the　stronger　charge-induced　interactions　between　the　charged　MOF　skeleton　and　the　easily　polarized　C-2　hydrocarbons　(C(2)s),　BUT-52　was　used　for　C(2)s　over　CH4　and　shows　both　high　adsorption　heats　of　C(2)s　and　selective　separation　abilities　for　C(2)s/CH4.　Furthermore,　BUT　52　also　displays　efficient　mercury　adsorption　resulting　from　the　stronger-binding　ability　beween　the　sulfur　and　the　mercury　and　can　remove　92%　mercury　from　methanol　solution　even　with　the　initial　concentration　as　low　as　100　mg/L.　The　results　in　this　work　indicate　the　feasibility　of　BUT-52　for　the　separation　of　light　hydrocarbons　and　efficient　adsorption/removal　of　mercury.