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Author:

陈薪宇 (陈薪宇.) | 张红胜 (张红胜.) (Scholars:张红胜) | 吴同超 (吴同超.)

Indexed by:

CQVIP

Abstract:

EZH2(enhancer of zeste homolog 2)作为重要的表观遗传修饰物,是PcG(Polycomb group)蛋白家族的重要成员之一,在调控基因表达的过程中起关键作用.EZH2主要对组蛋白H3K27进行甲基化,从而沉默下游基因.它在细胞增殖、分化及肿瘤形成方面都有重要作用.特别是近年来的研究表明,EZH2与很多恶性肿瘤的转移和侵略有关.随着对其研究的深入,EZH2将有望在新药作用靶点及疾病治疗方面发挥作用.

Keyword:

胚胎干细胞 肿瘤 EZH2 组蛋白脱乙酰酶

Author Community:

  • [ 1 ] [陈薪宇]北京工业大学
  • [ 2 ] [张红胜]北京工业大学
  • [ 3 ] [吴同超]北京工业大学

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Source :

生物技术通讯

ISSN: 1009-0002

Year: 2014

Issue: 5

Volume: 25

Page: 723-726

Cited Count:

WoS CC Cited Count: 0

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count: 6

Chinese Cited Count:

30 Days PV: 1

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