With　the　development　of　communications　industry,　mobile　phone　plays　an　important　role　in　daily　life.　Whether　or　not　the　electromagnetic　radiation　emitted　by　mobile　phone　causes　any　adverse　effects　on　brain　function　has　become　of　a　great　concern.　This　paper　investigated　the　effect　of　electromagnetic　field　on　spatial　learning　and　memory　in　rats.　32　trained　Wistar　rats　were　divided　into　two　groups:　exposure　group　and　control　group.　The　exposure　group　was　exposed　to　916　MHz,　10w/m2　mobile　phone　electromagnetic　field　(EMF)　6　h　a　day,　5　days　a　week,　10　weeks.　The　completion　time,　number　of　total　errors　and　the　neuron　discharge　signals　were　recorded　while　the　rats　were　searching　for　food　in　an　eight-arm　radial　maze　at　every　weekend.　The　neuron　signals　of　one　exposed　rat　and　one　control　rat　in　the　maze　were　obtained　by　the　implanted　microelectrode　arrays　in　their　hippocampal　regions.　It　can　be　seen　that　during　the　weeks　4-5　of　the　experiment,　the　average　completion　time　and　error　rate　of　the　exposure　group　were　longer　and　larger　than　that　of　control　group　(p　＜　0.05).　During　the　weeks　1-3　and　6-9,　they　were　close　to　each　other.　The　hippocampal　neurons　showed　irregular　firing　patterns　and　more　spikes　with　shorter　interspike　interval　during　the　whole　experiment　period.　It　indicates　that　the　916　MHz　EMF　influence　learning　and　memory　in　rats　to　some　extent　in　a　period　during　exposure,　and　the　rats　can　adapt　to　long-term　EMF　exposure.