The　effect　of　the　limb　salvage　of　the　treatment　of　Osteosarcoma　Consolidated　with　Obvious　Pathological　Fractures　is　not　very　well,　the　purpose　of　this　paper　is　to　track　the　efficacy　of　limb　salvage　treatment　when　the　patients　accepted　the　artery　intervention　chemotherapy　and　enclosed　2　clinical　case-reports.　From　January　2003　to　September　2005,　2　clinical　cases　which　one　is　a　male,　29　years　old,　was　confirmed　osteosarcoma　on　the　left　distal　femur,　and　the　other　is　a　female,　15　years　old　and　has　osteosarcoma　on　the　right　arm　with　obvious　pathological　fracture.　After　receiving　arterial　chemotherapy　pump　embedded,　then　started　chemotherapy　after　the　tumor　biopsy,　and　the　next　process　prosthesis　replacement　in　limb　salvage　surgery　after　5　times　chemotherapy,　follow　on　the　next　5　times　chemotherapy　after　the　surgery.　With　an　average　follow-up　70　months,　there　are　no　postoperative　infection　and　prosthesis　loosening　found,　also　didn＇t　detected　tumor　recurrence　and　metastasis,　and　the　limb　function　recovered　well.　With　the　effective,　neoadjuvant　chemotherapy　and　comprehensive　treatment,　salvage　treatment　is　not　the　contraindication　of　the　patients　with　pathological　fractures　of　combined　primary　osteosarcoma,　and　the　treatment　with　long-term　follow-up　effectively.