Relatively　few　reported　works　have　dealt　with　wastewaters　arising　from　amoxillin　manufacture.　To　develop　a　treatment　process　for　one　such　wastewater,　several　physicochemical　methods　such　as　coagulation,　ultrafiltration,　and　Fenton　oxidation　(FO),　have　been　investigated.　Among　these　methods,　FO　proved　effective.　Consequently　the　method　was　further　investigated　to　identify　the　appropriate　H2O2/FeSO4　ratio,　FeSO4　and　H2O2　concentrations,　and　reaction　pH　and　temperature.　In　relation　to　the　wastewater,　a　suitable　H2O2/FeSO4　weight　ratio　was　5:1　(molar　ratio:　22.4:1)　with　H2O2　and　FeSO4　concentrations　at　20　g/L,　4　g/L,　respectively.　The　corresponding　pH　range　was　2.0-4.0　while　the　reaction　temperature　was　60　degrees　C.　Given　these　conditions,　wastewater　total　organic　carbon　was　reduced　by　48.8-49.4%.　After　FO　treatment,　reverse　osmosis　(RO)　effectively　reduced　the　dissolved　salt　content.　The　contribution　of　FO　and　RO　pretreatment　improved　the　wastewater＇s　biodegradability　thus　making　a　downstream　biotreatment　polishing　process　viable.