Wastewater　from　the　synthesizing　of　amoxillin　is　characterized　by　its　very　high　TOC　and　low　biodegradability　and　the　presence　of　organic　solvents　and　dissolved　salts.　These　hamper　direct　biological　or　membrane-based　treatments.　A　combined　process　of　extraction　(EX),　Fenton　oxidation　(FO)　and　a　two-stage　reverse　osmosis　(RO)　was　proposed　to　treat　such　wastewater.　EX　and　FO　were　performed　in　a　serial　approach　to　function　as　the　pretreatments　to　remove　the　solvents　and　other　organics　before　RO　treatment.　It　was　noted　the　appropriate　phase　ratio　(A/O)　was　1:　1　and　the　contact　time　was　3　h.　Appropriate　dosages　of　FeSO(4)　and　H(2)O(2)　were　10　g/l　and　2　g/l,　respectively.　Under　the　appropriate　conditions,　TOC　can　be　reduced　by　50.6%　and　37.8%　in　the　EX　and　FO　units,　respectively.　TOC　can　be　further　reduced　10.1%　and　1.2%　in　the　first　and　second　RO　processes,　respectively.　There　was　consequently　an　overall　TOC　removal　efficiency　of　99.7%　after　the　whole　process　of　EX-FO-RO-RO.　Dissolved　salts　were　also　greatly　removed　during　the　two-stage　RO　process.　The　observations　by　using　SEM　showed　that　the　RO　membrane　can　be　protected　well　by　the　pretreatments　of　EX　and　FO.