This　paper　reports　a　synergistic　design　of　high-performance　BCC　high-entropy　alloy　based　on　the　combined　consideration　of　the　principles　of　intrinsic　ductility　of　elements,　maximum　atomic　size　difference　for　solid　solution　strengthening　and　the　valence　electron　concentration　criterion　for　ductility.　The　single-phase　BCC　HfNbTaTiV　alloy　thus　designed　exhibited　a　high　compressive　yield　strength　of　1350　MPa　and　a　high　compressive　ductility　of　＞45　%　at　the　room　temperature.　This　represents　a　50　%　increase　in　yield　strength　relative　to　a　HfNbTaTiZr　alloy.　This　is　attributed　to　the　maximized　solid　solution　strengthening　effect　caused　by　lattice　distortion,　which　is　estimated　to　be　1094　MPa.　The　alloy　was　also　able　to　retain　53　%　of　its　yield　strength　and　77　%　of　its　ductility　at　700　degrees　C.　These　properties　are　superior　to　those　of　most　refractory　BCC　high-entropy　alloys　reported　in　the　literature.　(C)　2021　Published　by　Elsevier　Ltd　on　behalf　of　The　editorial　office　of　Journal　of　Materials　Science　&　Technology.