Dynamization,　increasing　the　interfragmentary　movement　(IFM)　by　reducing　the　fixation　stiffness　from　a　rigid　to　a　more　flexible　condition,　is　widely　used　clinically　to　promote　fracture　healing.　However,　it　remains　unknown　how　dynamization　degree　(relative　change　in　fixation　stiffness/IFM　from　a　rigid　to　a　flexible　fixation)　affects　bone　healing　at　various　stages.　To　address　this　issue,　we　used　a　fuzzy　logic-based　mechano-regulated　tissue　differentiation　algorithm　on　published　experimental　data　from　a　sheep　osteotomy　healing　model.　We　applied　a　varied　degree　of　dynamization,　from　0　(fully　rigid　fixation)　to　0.9　(90%　reduction　in　stiffness　relative　to　the　rigid　fixation)　after　1,　2,　3,　and　4　weeks　of　osteotomy　(R1wF,　R2wF,　R3wF,　and　R4wF)　and　computationally　evaluated　bone　regeneration　and　biomechanical　integrity　over　the　healing　process　of　8　weeks.　Compared　with　the　constant　rigid　fixation,　early　dynamization　(R1wF　and　R2wF)　led　to　delays　in　bone　bridging　and　biomechanical　recovery　of　the　osteotomized　bone.　However,　the　effect　of　early　dynamization　on　healing　was　dependent　of　the　degree　of　dynamization.　Specifically,　a　higher　dynamization　degree　(e.g.,　0.9　for　R1wF)　led　to　a　prolonged　delay　in　bone　bridging　and　largely　unrecovered　bending　stiffness　(48%　relative　to　the　intact　bone),　whereas　a　moderate　degree　of　dynamization　(e.g.,　0.5　or　0.7)　significantly　enhanced　bone　formation　and　biomechanical　properties　of　the　osteotomized　bone.　These　results　suggest　that　dynamization　degree　and　timing　interactively　affect　the　healing　process.　A　combination　of　early　dynamization　with　a　moderate　degree　could　enhance　the　ultimate　biomechanical　recovery　of　the　fractured　bone.