The　implementation　of　two-dimensional　materials　into　memristor　architectures　has　recently　been　a　new　research　focus　by　taking　advantage　of　their　atomic　thickness,　unique　lattice,　and　physical　and　electronic　properties.　Among　the　van　der　Waals　family,　Bi2O2Se　is　an　emerging　ternary　two-dimensional　layered　material　with　ambient　stability,　suitable　band　structure,　and　high　conductivity　that　exhibits　high　potential　for　use　in　electronic　applications.　In　this　work,　we　propose　and　experimentally　demonstrate　a　Bi2O2Se-based　memristor-aided　logic.　By　carefully　tuning　the　electric　field　polarity　of　Bi2O2Se　through　a　Pd　contact,　a　reconfigurable　NAND　gate　with　zero　static　power　consumption　is　realized.　To　provide　more　knowledge　on　NAND　operation,　a　kinetic　Monte　Carlo　simulation　is　carried　out.　Because　the　NAND　gate　is　a　universal　logic　gate,　cascading　additional　NAND　gates　can　exhibit　versatile　logic　functions.　Therefore,　the　proposed　Bi2O2Se-based　MAGIC　can　be　a　promising　building　block　for　developing　next-generation　in-memory　logic　computers　with　multiple　functions.