With　improvement　of　industrial　technology　and　people＇s　living　standard,　the　refrigeration　plants　of　evaporation　temperatures　in　the　range　of　-40degreesC　to　-80degreesC　are　increasingly　used　in　many　industry　and　commerce　departments.　The　performances　of　binary　cascade　refrigeration　system　with　R22/R23　and　two-stage　refrigeration　system　with　R22　were　comprehensively　analyzed　by　the　aid　of　the　property　program　of　real　refrigerants　and　the　characteristics　of　actual　semi-hermetic　reciprocating　compressors.　The　results　show　that:　when　the　evaporation　temperature　varies　from　-40degreesC　to　-53degreesC　with　constant　condensation　temperature　of　40degreesC,　two-stage　refrigeration　system　is　suitable　to　use　in　the　range　of　-40degreesC　to　-53degreesC;　when　evaporation　temperature　varies　from　-53degreesC　to　-80degreesC　with　constant　condensation　temperature　of　40degreesC,　the　refrigerating　capacity　and　energy　efficiency　ratio　(EER)　of　binary　cascade　system　are　higher　than　those　of　two-stage　system,　thus　the　cascade　system　is　suitable　to　the　use　in　the　temperature　range　of　-53degreesC　to　-80degreesC.