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Author:

Yang, Chunlan (Yang, Chunlan.) | Ren, Jiechuan (Ren, Jiechuan.) | Li, Wan (Li, Wan.) | Lu, Min (Lu, Min.) | Wu, Shuicai (Wu, Shuicai.) | Chu, Tongpeng (Chu, Tongpeng.)

Indexed by:

SSCI Scopus SCIE PubMed

Abstract:

In patients with Alzheimer's Disease (AD), the hippocampal network has been extensively investigated in previous studies; however, little is known about the morphological network associated with the hippocampus in the AD patients. A total of 68 patients with AD and another 68 gender and age matched healthy subjects were studied. Individual-level morphological hippocampal networks were constructed based on volume and texture features extracted from MRI to study the connections between bilateral hippocampus and 11 other subcortical gray matter structures. The relationship between morphological connections and Mini-Mental State Examination (MMSE) scores was also studied. Connections between bilateral hippocampus and bilateral thalamus, bilateral putamen were significant differences between the AD patients and controls (p < 0.05). There were significantly different in bilateral hippocampal connectivity, and for the left hippocampus, the connection to the right caudate were found to be statistically significant. The morphological connections between left hippocampus and bilateral thalamus (left: R = 0.371, p < 0.001; right: R = 0.411, p < 0.001), bilateral putamen (left: R = 0.383, p < 0.001; right: R = 0.348, p < 0.001), right hippocampus and bilateral thalamus (left: R = 0.370, p < 0.001; right: R = 0.387, p < 0.001), left putamen (R = 0.377, p < 0.001) were significantly positively correlated with the MMSE scores. Similar patterns were observed for left and right hippocampal connectivity and the connections highly associated with MMSE scores were also within the abnormal connections in AD patients.

Keyword:

Alzheimer&apos Morphological hippocampal networks s disease Cognitive

Author Community:

  • [ 1 ] [Yang, Chunlan]Beijing Univ Technol, Dept Environm & Life, Beijing 100020, Peoples R China
  • [ 2 ] [Li, Wan]Beijing Univ Technol, Dept Environm & Life, Beijing 100020, Peoples R China
  • [ 3 ] [Lu, Min]Beijing Univ Technol, Dept Environm & Life, Beijing 100020, Peoples R China
  • [ 4 ] [Wu, Shuicai]Beijing Univ Technol, Dept Environm & Life, Beijing 100020, Peoples R China
  • [ 5 ] [Ren, Jiechuan]Capital Med Univ, Beijing Tiantan Hosp, Dept Epilepsy, Neurol Ctr, Beijing 100070, Peoples R China
  • [ 6 ] [Chu, Tongpeng]Qingdao Univ, Yantai Yuhuangding Hosp, Dept Radiol, Affiliated Hosp, Yantai 264000, Shandong, Peoples R China

Reprint Author's Address:

  • [Chu, Tongpeng]Qingdao Univ, Yantai Yuhuangding Hosp, Dept Radiol, Affiliated Hosp, Yantai 264000, Shandong, Peoples R China

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Source :

BRAIN AND COGNITION

ISSN: 0278-2626

Year: 2021

Volume: 151

2 . 5 0 0

JCR@2022

ESI Discipline: NEUROSCIENCE & BEHAVIOR;

ESI HC Threshold:71

JCR Journal Grade:2

Cited Count:

WoS CC Cited Count: 4

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 2

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