By　means　of　experimental　research　and　theoretical　analysis,　the　nonuniform　evolution　characteristics　of　rock　friction　and　sliding　were　studied.　Using　digital　speckle　correlation　(DIC)　as　observation　method,　the　whole　process　of　friction　and　sliding　of　a　granite　specimen　in　double-sided　shear　experiment　is　studied.　A　spring　slider　model　considering　the　microscopic　characteristics　of　interface　asperities　was　established　to　simulate　the　microscopic　process　of　rock　friction　and　sliding.　By　comparing　the　theoretical　analysis　results　with　the　experimental　results,　the　effect　of　interface　nonuniformity　on　rock　friction　sliding　instability　is　studied.　The　results　demonstrated　that,　with　the　increase　of　nonuniformity　of　sliding　interface,　the　degree　of　local　instability　before　stick-slip　decreases,　the　stick-slip　period　shortens,　and　the　value　of　shear　drop　during　stick-slip　period　decreases.　The　nonuniformity　of　sliding　interface　will　increase　after　local　instability.