This　paper　investigated　the　multi-scale　prediction　of　long-term　creep　in　river　sand　(RS)　concrete　and　manufactured　sand　(MS)　concrete　and　analyzed　the　effect　of　the　interfacial　transition　zone　(ITZ)　around　the　aggregate　on　the　creep　properties　of　concrete.　Uniaxial　compressive　creep　tests　were　conducted　on　the　concrete　for　a　duration　of　360　d.　The　creep　kinetic　properties　of　the　paste　matrix　and　ITZ　were　obtained　by　microindentation　test.　The　properties　of　ITZ　were　determined　by　the　backscattered　electron　(BSE)　image　threshold　segmentation　technique　and　the　Lu　&　Torquato　model.　Finally,　the　predicted　concrete　creep　modulus　was　obtained　through　the　calculation　of　creep　homogenization,　and　the　accuracy　of　multi-scale　creep　prediction　when　considering　different　ITZ　cases　was　discussed.　The　results　show　that　under　the　same　water-binder　ratio,　the　thickness　of　ITZ　around　MS　was　larger,　the　creep　modulus　was　smaller　and　the　volume　fraction　was　larger　compared　with　that　of　ITZ　around　RS.　In　the　multi-scale　homogenization　calculation　of　the　concrete　long-term　creep,　the　prediction　accuracy　of　the　computational　model　increased　with　the　raised　of　the　considered　ITZ　types.　The　prediction　accuracy　obtained　when　all　ITZs　were　considered　was　improved　by　more　than　46.3%　compared　to　that　when　no　ITZs　were　considered.