High-throughput　laser　drilling　is　crucial　for　the　processing　of　large-area　micro-hole　arrays,　but　the　local　heat　accumulation　effect　in　the　processing　significantly　limits　the　fabrication　quality,　especially　for　multi-beam　laser　micro-drilling.　Although　cooling　methods　such　as　water　or　airflow　is　applied　to　enhance　heat　dissipation,　the　heat　input　regulation　is　a　convenient　and　effective　way　to　improve　the　processing　quality.　In　this　work,　a　novel　temporal　and　spatial　heat　input　regulation　strategy　is　proposed　for　multi-beam　laser　micro-drilling　to　effectively　suppress　the　local　heat　accumulation　during　the　processing.　The　strategy　consists　of　a　scanning　path　planning　model　and　an　optimization　method　of　key　drilling　parameters.　The　scanning　path　planning　model　is　established　based　on　the　temperature　field　of　the　workpiece,　which　is　dynamically　calculated　using　a　transient　finite　-difference　method　(FDM).　In　addition,　an　optimization　method　is　proposed　to　match　the　drilling　parameters　with　the　designated　scanning　path.　Via　this　heat　input　regulation　strategy,　a　more　homogeneous　temperature　distribution　can　be　obtained　in　the　multi-beam　laser　drilling　of　micro-hole　arrays.　The　maximum　temperature　and　duration　of　overheating　that　causes　material　oxidation　are　decreased　by　10%,　and　50%,　respectively.　With　the　realization　of　high-quality　(recast-free)　and　high-throughput　(2430　micro-holes　in　210　s,　or　12　micro-holes/　s),　the　proposed　strategy　shows　a　promising　prospect　in　the　multi-beam　drilling　of　micro-hole　arrays　and　other　laser　processing　with　possible　heat　accumulation,　such　as　large-area　surface　texture　and　precise　engraving　of　micro-nano　structures.