Xylene　is　one　of　the　main　components　of　volatile　organic　compounds　(VOCs),　the　catalytic　oxidation　of　xylene　has　been　studied.　In　this　work,　the　manganese-cobalt　mixed　oxide　catalysts　for　the　xylene　removal　have　been　prepared　by　one　step　direct　decomposition　method　with　the　aid　of　glucose.　The　physicochemical　properties　of　the　catalysts　were　characterized　by　TG,　XRD,　TEM,　BET,　TPR　and　XPS.　The　catalytic　experiments　results　show　that　the　Mn-Co　catalysts　are　composite　oxides　composed　of　Mn2O3　and　Co3O4.　The　Mn1Co1.4Ox　catalyst　with　the　molar　ratio　of　Mn　to　Co　of　1:1.4　has　excellent　oxidation　removal　performance　of　xylene.　At　the　space　velocity　of　20000　mL　(g·h)−1　and　the　concentration　xylene　of　500　ppm,　the　temperature　of　complete　conversion　of　xylene　is　210　°C,　which　is　related　to　the　developed　pore　structure,　high　specific　surface　area,　excellent　reduction　performance,　abundant　adsorbed　oxygen　species,　coexistence　and　interaction　of　polyvalent　species.　The　space　structure　and　competitive　adsorption　of　reactants　make　the　oxidation　performance　of　low　polarity　p-xylene　better.　The　participation　of　water　vapor　reduced　the　catalytic　performance　of　the　reaction　system　by　12-19%,　which　is　related　to　the　ads-desorption　of　water　molecules　and　the　decomposition　of　active　components.　©　2023