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Author:

Yang, Kun (Yang, Kun.) | Li, Qiang (Li, Qiang.) (Scholars:李强) | Liu, Hao-Li (Liu, Hao-Li.) | Chen, Chin-Kuo (Chen, Chin-Kuo.) | Huang, Cheng-Wei (Huang, Cheng-Wei.) | Chen, Jheng-Ru (Chen, Jheng-Ru.) | Tsai, Yu-Wei (Tsai, Yu-Wei.) | Zhou, Zhuhuang (Zhou, Zhuhuang.) | Tsui, Po-Hsiang (Tsui, Po-Hsiang.)

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Scopus SCIE PubMed

Abstract:

High-intensity focused ultrasound (HIFU) is a well-accepted tool for noninvasive thermal therapy. To control the quality of HIFU treatment, the focal spot generated in tissues must be localized. Ultrasound imaging can monitor heated regions; in particular, the change in backscattered energy (CBE) allows parametric imaging to visualize thermal information in the tissue. Conventional CBE imaging constructed in the spatial domain may be easily affected by noises when the HIFU focal spot is visualized. This study proposes frequency-domain CBE imaging to improve noise tolerance and image contrast in HIFU focal spot monitoring. Phantom experiments were performed in a temperature-controlled environment. HIFU of 2.12MHz was applied to the phantoms, during which a clinical scanner equipped with a 3-MHz convex array transducer was used to collect raw image data consisting of backscattered signals for B-mode, spatial-, and frequency-domain CBE imaging. Concurrently, temperature changes were measured at the focal spot using a thermocouple for comparison with CBE values by calculating the correlation coefficient r. To further analyze CBE image contrast levels, a contrast factor was introduced, and an independent t-test was performed to calculate the probability value p. Experimental results showed that frequency-domain CBE imaging performed well in thermal distribution visualization, enabling quantitative detection of temperature changes. The CBE value calculated in the frequency domain also correlated strongly with that obtained using the conventional spatial-domain approach (r=0.97). In particular, compared with the image obtained through the conventional method, the contrast of the CBE image obtained using the method based on frequency-domain analysis increased by 2.5-fold (4dB; p<0.05). Frequency-domain computations may constitute a new strategy when ultrasound CBE imaging is used to localize the focal spot in HIFU treatment planning.

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Author Community:

  • [ 1 ] [Yang, Kun]Tianjin Univ, Sch Microelect, Tianjin, Peoples R China
  • [ 2 ] [Li, Qiang]Tianjin Univ, Sch Microelect, Tianjin, Peoples R China
  • [ 3 ] [Liu, Hao-Li]Chang Gung Univ, Dept Elect Engn, Taoyuan, Taiwan
  • [ 4 ] [Chen, Chin-Kuo]Chang Gung Mem Hosp, Dept Otolaryngol Head & Neck Surg, Taoyuan, Taiwan
  • [ 5 ] [Chen, Chin-Kuo]Chang Gung Univ, Taoyuan, Taiwan
  • [ 6 ] [Huang, Cheng-Wei]Chang Gung Univ, Coll Med, Dept Med Imaging & Radiol Sci, Taoyuan, Taiwan
  • [ 7 ] [Chen, Jheng-Ru]Chang Gung Univ, Coll Med, Dept Med Imaging & Radiol Sci, Taoyuan, Taiwan
  • [ 8 ] [Tsai, Yu-Wei]Chang Gung Univ, Coll Med, Dept Med Imaging & Radiol Sci, Taoyuan, Taiwan
  • [ 9 ] [Tsui, Po-Hsiang]Chang Gung Univ, Coll Med, Dept Med Imaging & Radiol Sci, Taoyuan, Taiwan
  • [ 10 ] [Zhou, Zhuhuang]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing, Peoples R China
  • [ 11 ] [Tsui, Po-Hsiang]Chang Gung Univ, Med Imaging Res Ctr, Inst Radiol Res, Taoyuan, Taiwan
  • [ 12 ] [Tsui, Po-Hsiang]Chang Gung Mem Hosp Linkou, Taoyuan, Taiwan
  • [ 13 ] [Tsui, Po-Hsiang]Chang Gung Mem Hosp Linkou, Dept Med Imaging & Intervent, Taoyuan, Taiwan

Reprint Author's Address:

  • [Tsui, Po-Hsiang]Chang Gung Univ, Coll Med, Dept Med Imaging & Radiol Sci, Taoyuan, Taiwan;;[Zhou, Zhuhuang]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing, Peoples R China;;[Tsui, Po-Hsiang]Chang Gung Univ, Med Imaging Res Ctr, Inst Radiol Res, Taoyuan, Taiwan;;[Tsui, Po-Hsiang]Chang Gung Mem Hosp Linkou, Taoyuan, Taiwan;;[Tsui, Po-Hsiang]Chang Gung Mem Hosp Linkou, Dept Med Imaging & Intervent, Taoyuan, Taiwan

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Source :

SCIENTIFIC REPORTS

ISSN: 2045-2322

Year: 2020

Issue: 1

Volume: 10

4 . 6 0 0

JCR@2022

ESI Discipline: Multidisciplinary;

ESI HC Threshold:349

Cited Count:

WoS CC Cited Count: 11

SCOPUS Cited Count: 14

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 1

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