The　high　cost　of　laser　powder　bed　fusion　(LPBF)　fabricated　high-strength　Sc　containing　aluminium　alloy　hinders　its　applications.　To　reduce　the　cost,　we　reported　a　LPBF　fabricated　strong　and　ductile　Al-Mn-Mg-Sc-Zr　alloy　using　large　layer　thicknesses　to　improve　the　fabrication　efficiency　on　coarse　powder　particles.　A　high　relative　density　exceeding　99.2%　was　achieved　at　layer　thicknesses　up　to　120　mu　m.　In　post-process　heat-treated　specimens,　the　yield　strength　only　had　a　slight　6%　decrease　from　layer　thickness　of　30　to　120　mu　m;　such　a　decrease　in　strength　was　attributed　to　the　larger　grain　size　resulted　from　the　adopted　larger　layer　thickness.　The　fabricated　sample　at　layer　thickness　of　120　mu　m　still　exhibited　high　tensile　yield　strength　of　472　MPa　and　fracture　strain　of　similar　to　10%.　This　work　showed　a　successful　application　of　improving　the　LPBF　fabrication　efficiency　of　highstrength　Al-Mn-Mg-Sc-Zr　alloy　using　large　layer　thickness　in　LPBF　process.