This　study　proposed　a　multiaxial　variable　temperature　and　amplitude　damage　assessment　model　to　predict　the　variable　temperature　and　amplitude　fatigue　life　of　high-temperature　alloys,　which　are　often　subjected　to　varying　multiaxial　mechanical　and　temperature　loads.　To　validate　the　proposed　model,　seven　variable　temperature　and　amplitude　fatigue　tests　were　conducted　on　GH4169　nickel-based　high-temperature　alloy.　The　proposed　model　shows　good　accuracy　and　reliability　in　predicting　the　lifetime　of　high-temperature　alloy　components　under　multiaxial　mechanical　and　temperature　loads.　©　Published　under　licence　by　IOP　Publishing　Ltd.