The　digital　economy　has　become　an　important　driving　force　for　countries　to　rebuild　economic　development　during　COVID-19.　However,　its　effect　on　regional　economic　resilience　is　still　unclear.　The　purpose　of　this　paper　is　to　study　the　theoretical　mechanism　of　the　digital　economy　service　industry　affecting　regional　economic　resilience　and　to　construct　an　econometric　model　to　empirically　test　the　overall　impact　of　the　digital　economy　on　regional　economic　resilience,　as　well　as　the　threshold　effect　of　the　level　of　manufacturing　development.　The　study　finds　that　(1)　the　digital　economy　service　industry　has　a　significant　positive　impact　on　regional　economic　resilience.　(2)　With　improvement　in　the　level　of　manufacturing　development,　the　positive　contribution　of　the　digital　economy　service　industry　to　the　regional　economic　resilience　is　enhanced,　and　the　effective　coupling　of　the　digital　economy　service　industry　and　the　manufacturing　industry　can　improve　the　regional　economic　resilience　to　a　greater　extent.　Therefore,　this　paper　proposes　that,　to　improve　the　resilience　of　the　regional　economy,　we　should　not　only　improve　the　level　of　digital　technology　of　the　digital　economy　service　industry,　but　also　focus　on　the　application　of　digital　technology　in　the　real　economy,　especially　in　the　manufacturing　industry,　encourage　the　digital　transformation　of　enterprises,　and　improve　the　digital　governance　capacity　of　the　government.