The　development　of　cost-effective　catalysts　with　excellent　chlorine　resistance　and　harmful　by-products　inhibition　is　important　for　the　environmentally　friendly　purification　of　multi-component　volatile　organic　compounds　(VOCs　and　chlorine-containing　VOCs　(CVOCs)).　In　this　work,　the　Sn-doped　Silicalite-1-supported　Ru　(Ru@Silicalite-1Sn-x,　and　x　is　the　molar　ratio　of　Si/Sn)　samples　were　prepared　using　a　hydrothermal　strategy,　and　catalytic　activities　of　these　materials　were　investigated　for　the　oxidative　removal　of　mixed　VOCs　(dichloromethane　(DCM)　and　toluene).　The　Ru@Silicalite-1-Sn-50　sample　with　tightly　coupled　redox　and　acidic　sites　exhibited　high　catalytic　activity　(T90%　=　287　degrees　C　for　toluene　oxidation　and　T90%　=　361　degrees　C　for　DCM　oxidation　at　a　space　velocity　of　40,000　mL/(g　h);　specific　reaction　rate　and　turnover　frequency　(TOFRu)　for　toluene　oxidation　at　170　degrees　C　were　9.67　mu　mol/(gcat　h)　and　0.98　x　10-3　s-1,　and　specific　reaction　rate　and　TOFRu　for　DCM　oxidation　at　200　degrees　C　were　3.84　mu　mol/(gcat　h)　and　0.46　x　10-3　s-1,　respectively),　excellent　catalytic　stability　(within　100　h　of　on-stream　oxidation　at　380　degrees　C),　and　effective　inhibition　of　toxic　chlorine-containing　by-products　formation　in　the　oxidation　of　(DCM　and　toluene).　The　doping　of　Sn　could　effectively　anchor　the　Ru　atoms　to　result　in　single-atom　dispersion　of　Ru　and　generate　oxygen　vacancies,　and　optimized　the　synergistic　interaction　between　Lewis　acid　sites　and　Br　&　oslash;nsted　acid　sites.　The　high　concentration　of　oxygen　vacancies　and　enriched　Br　&　oslash;nsted　acid　sites　promoted　the　cleavage　of　C-Cl　bonds　in　DCM　and　accelerated　the　desorption　of　Cl　species　as　inorganic　chlorine.　In　the　meanwhile,　the　strong　electron　transfer　within　the　Sn-O-Si　bond　increased　the　Lewis　acidity,　which　promoted　the　deep　oxidation　of　dechlorinated　intermediates/other　intermediates　over　Ru@Silicalite-1-Sn-50.　We　believe　that　the　present　work　provides　a　feasible　and　promising　strategy　for　the　design　of　efficient　catalysts　for　the　destruction　of　multicomponent　VOCs　and　CVOCs　in　an　industrial　scale.