Depressurization　exploitation　of　hydrate　in　methane　hydrate-bearing　sediments　(MHBS)　causes　changes　in　sediment　effective　stress,　deformation,　and　hydrate　content,　often　resulting　in　decreased　permeability　which　reduces　gas　production　efficiency.　To　investigate　the　evolution　of　MHBS　permeability　subjected　to　these　changing　conditions,　permeability　tests　on　MHBS　of　different　methane　hydrate　saturation　level　were　performed　during　isotropic　compression　and　drained　triaxial　shearing　under　a　wide　range　of　effective　stress　conditions.　The　results　obtained　from　compression　tests　indicate　that　with　increasing　effective　stress,　MHBS　permeability　first　decreases　rapidly　and　then　tends　to　stabilize,　and　the　influence　of　hydrate　saturation　on　permeability　gradually　reduces.　The　permeability　during　the　triaxial　shear　process　is　closely　related　to　volumetric　deformation,　with　shear-contraction　specimen　exhibiting　continuous　decrease　in　permeability　and　shear-dilation　specimens　experiencing　an　increase　in　permeability.　Unique　correlation　between　permeability　with　effective　void　ratio　(affected　by　hydrate　saturation)　was　observed　at　low　confining　pressure　and　early　stage　of　shear.　However,　this　relationship　becomes　nonunique　under　increased　pressure　and　shear　strain.　Thus,　a　unified　MHBS　permeability　model　for　a　range　of　conditions　is　established　based　on　the　observed　relationship　between　MHBS　permeability　and　effective　void　ratio,　considering　the　influence　of　confining　stress,　shear　strain,　and　the　breakage　of　sediment　particles.