Many　studies　have　shown　the　functional　relevance　of　cross-modal　plasticity　in　blind　men.　However,　few　researches　have　focused　on　whether　such　functional　plasticity　is　associated　with　macroscopic　changes　of　structural　anatomy　in　brain　regions.　Fortunately,　deformation　based　morphometry　(DBM)　provides　an　important　tool　for　the　computational　anatomy　research.　In　this　study　we　detected　the　changes　of　regional　volume　in　brain　structures　between　the　blind　men　and　normal　controls　with　DBM　method.　Information　of　the　difference　is　derived　from　the　deformation　field　acquired　during　HAMMER　non-rigid　registration.　The　experimental　results　show　that　the　regions　expanded　in　the　blind　men＇s　brain　are　located　at　Brodmann　19,31　while　the　contracted　regions　located　at　Brodmann　17,18.　This　research　is　very　helpful　to　discover　the　relationship　between　structural　anatomy　and　functional　data　of　blind　men　at　a　macroscopic　level　from　neuroimaging　perspective.　©　2008　Springer-Verlag.