Space-time　digital　holography　(STDH)　exploits　the　object　motion　to　record　the　hologram　in　a　hybrid　ST　domain.　This　representation　adds　new　capabilities　to　conventional　DH,　e.g.,　unlimited　field　of　view　and　variable　phase　shifting.　This　is　the　best　candidate　for　imaging　biological　samples　flowing　in　microfluidic　channels.　Here,　we　show　that　STDH　is　able　to　improve　the　spatial　resolution　as　well.　Different　from　other　super-resolution　approaches,　stitching　between　holograms　or　their　spectra　is　no　longer　required.　Moreover,　we　introduce　a　new　oblique　STDH　modality　to　record　and　process　hybrid　ST　representations.　This　allows　improving　resolution　in　2D　with　one　single　object　scan,　paving　the　way　to　the　use　of　STDH　for　super-resolution　imaging　onboard　microfluidic　devices.　(C)　2018　Optical　Society　of　America