The　sensitivity　analysis(SA)　based　on　experimental　data　is　a　reliable　and　effective　method,　the　basic　SA　theory　based　on　the　experimental　data　in　ANSYS　is　presented　in　detail,　which　can　be　a　reference　of　structural　SA　u-sing　ANSYS.　A　Schwedler　single-layer　dome　is　analyzed　by　using　ANSYS,　and　the　sensitivity　values　of　several　structural　responses　to　dome　members　are　calculated,　which　quantify　the　influence　degree　of　members　to　the　structural　responses,　so　the　result　can　be　for　a　reference　of　the　design　and　response　control　of　the　single-layer　dome.　The　analysis　of　the　calculated　results　verifies　the　reliability　and　effectiveness　of　SA　based　on　experimental　data.