Objective:　To　prepare　and　evaluate　the　quality　of　chrysophanol　liposome.　Methods:　The　liposome　was　prepared　by　film-ultrasonic　wave　technology.　The　morphology,　entrapment,　size　distribution　and　stability　of　chrysophanol　liposome　were　studied.　Results:　The　optimal　formulation　was　drug/PC=3:30,　CHOL/PC=1:3,　at　45°C　reactive　temperature,　and　pH=8.2　in　buffer　solution.　The　size　of　obtained　liposome　was　uniform　and　entrapment　efficiency　reached　86.9%.　Conclusion:　Prepared　by　the　film-ultrasonic　wave　technology,　chrysophanol　is　highly　entrapped　into　liposome　with　good　stability.