To　explore　the　clinical　application　features　of　Qingkailing　injection　for　adolescent　patients.　This　study　was　based　on　the　information　from　the　hospitalized　patients　in　1998-2011　in　HIS　(hospital　information　system)　of　16　tertiary　hospitals　in　China.　615　adolescent　patients　with　Qingkailing　injection　were　used　to　investigate　the　clinical　characteristics　of　Qingkailing　injection.　Apriori　algo-rithm　was　adopted　to　establish　the　model,　and　Clementine　12.0　was　used　for　correlation　analysis.　The　results　showed　that　male　patients　(355　cases)　were　more　than　female　patients　(243　cases);　the　age　of　the　most　patients　was　under　14　years　old,　with　an　average　age　of　9.40　years　old;　the　hospital　stay　was　most　of　4-7　d;　the　patients　were　mostly　concentrated　in　pediatrics,　mainly　including　upper　respiratory　tract　infection;　outpatient　admission　to　the　majority　(451　cases,　accounting　for　75.54%).　The　traditional　Chinese　medicine　(TCM)　syndrome　mainly　included　phlegm-dampness　internal　resistance　(38.46%),　Qi　and　Yin　Deficiency　(11.54%),　Liver　qi　stagnation　(15.38%),　and　Yang　deficiency　syndrome　(11.54%);　the　highest　admission　rate　was　during　Slight　Cold　(13.01%).　In　combined　application,　the　most　common　western　medicine　pair　was　Cephalosporin　injection　+　Vitamin　C　(with　supporting　rate　of　24.6%)　and　the　most　common　TCM　pair　was　Shuanghuanglian　+　Ganmao　Qingre　granules　(with　supporting　rate　of　4.065%).　The　most　common　3　western　medicines　in　combined　use　were　Potassium　chloride　injection　+　Cephalosporin　injection　+　Vitamin　C　(supporting　rate　of　15.93%);　while　the　most　common　three　Chinese　medicines　were　Shuanghuanglian　+　Yunnan　Baiyao　+　Ganmao　Qingre　granules　(supporting　rate　of　1.138%).　Qingkailing　injection　was　also　widely　used　in　adolescent　patients;　the　diagnosis　and　use　were　basically　in　line　with　the　instructions;　men　were　slightly　more　than　women;　age　of　onset,　solar　terms　and　TCM　syndromes　were　highly　consistent.　Qingkailing　injection　was　mainly　combined　with　western　medicines　in　combined　drug　use,　and　Chinese　medicines　were　also　a-vailable.　Combined　drug　use　was　more　reasonable.　Based　on　the　results　of　the　real　world　HIS,　Qingkailing　injection　could　provide　the　idea　and　reference　for　regulating　the　medication　in　adolescent　patients.