To　analyze　the　drug　combination　characteristics　of　Qingkailing　injection　for　treating　abnormal　inflammatory　factors　such　as　elevated　white　blood　cells　and　C　reactive　protein　in　real　world.　The　patients　with　Qingkailing　injection　for　abnormal　C　reactive　proteins　and　abnormal　white　blood　cells　were　extracted　from　hospital　information　system　(HIS)　of　16　Class　3A　hospitals.　Then　the　basic　information,　traditional　Chinese　medicine　and　Western　medicine　diagnostic　information,　doctor＇s　advice　information,　and　laboratory　information　were　analyzed;　Apriori　algorithm　was　used　to　construct　the　models,　and　Clementine　12.0　was　used　for　correlation　analysis　to　analyze　the　clinical　medication　rules　and　drug　combination　characteristics　in　the　patients　with　Qingkailing　injection　for　treatment　of　elevated　C　reactive　protein　and　white　blood　cells　in　the　real　world.　The　results　of　the　study　showed　that　when　Qingkailing　injection　was　combined　with　one　kind　of　western　medicine　and　traditional　Chinese　medicine　in　treatment　of　patients　with　abnormal　C　reactive　protein,　vitamin　C　(159　cases,　74.30%)　and　Tanreqing　injection　(71　cases,　33.18%)　were　most　frequently　used;　when　it　was　combined　with　2　kinds　of　traditional　Chinese　medicines,　Xueshuantong　injection　plus　Tanreqing　injection　(support　degree　10.75%)　were　most　frequently　used.　When　Qingkailing　injection　was　combined　with　one　kind　of　western　medicine　and　traditional　Chinese　medicine　in　treatment　of　patients　with　abnormal　white　blood　cells,　vitamin　C　(596　cases,　56.02%)　and　Ganmao　Qingre　granules　(247　cases,　23.21%)　were　most　frequently　used;　when　it　was　combined　with　2　kinds　of　traditional　Chinese　medicines,　Shuanghuanglian+Ganmao　Qingre　granules　(support　degree　5.26%)　were　most　frequently　used.　In　the　patients　with　abnormal　C-reactive　protein　and　white　blood　cells,　its　combinations　with　antibiotics　and　nutritional　support　agents　were　most　common　from　the　pharmacological　perspective,　indicating　that　in　the　treatment　of　abnormal　C-reactive　protein,　white　blood　cells　and　other　increased　inflammatory　indicators,　Qingkailing　injection　was　most　frequently　combined　with　antibiotic　drugs　to　achieve　synergistic　effect.　Copyright©　by　the　Chinese　Pharmaceutical　Association.