The　general　sampling　inspection　solution　is　not　suitable　for　3D　printing　products　because　of　the　personality　of　such　products.　In　this　paper,　a　framework　for　3D　printed　maxillofacial　tumor　treatment　guide　inspection　was　proposed　to　achieve　a　more　accurate　detection,　which　includes　mechanic　system,　control　part　and　video　surveillance　part.　The　proposed　method　was　used　to　inspect　the　location　and　direction　of　the　hole　under　three　parts.　First,　the　3D　model　and　the　printed　product　were　aligned　in　the　unified　coordinates.　Then,　the　product　was　moved　to　the　suitable　view　based　on　the　location　and　direction　of　the　hole　on　the　3D　model　so　that　the　hole　would　be　in　the　center　of　the　image.　Finally,　the　hole　was　detected　and　shape　parameters　such　as　circularity,　aspect　ratio,　diameter　and　the　distance　between　the　neighboring　holes　were　extracted.　Based　on　these　parameters,　we　can　decide　if　the　hole　is　qualified.　The　experiments　demonstrate　that　the　proposed　method　raises　the　inspection　precision　and　speed,　in　comparison　to　manual　inspection.　Furthermore,　the　proposed　framework　can　be　extended　to　shape　consistency　inspection　of　other　3D　printing　products.　©　2017,　Editorial　Department　of　Journal　of　Beijing　University　of　Technology.　All　right　reserved.