Prevention　of　implant-associated　infections　at　an　early　stage　of　surgery　is　highly　desirable　for　the　long-term　efficacy　of　implants　in　dentistry　and　orthopedics.　Infection　prophylaxis　using　conventional　antibiotics　is　becoming　less　effective　due　to　the　development　of　bacteria　resistant　to　multiple　antibiotics.　An　ideal　strategy　to　conquer　bacterial　infections　is　the　local　delivery　of　antibacterial　agents.　Therefore,　antimicrobial　peptide　(AMP)　eluting　coatings　on　implant　surfaces　is　a　promising　alternative.　In　this　study,　the　feasibility　of　utilizing　TiO2　nanotubes　(TNTs),　processed　using　anodization,　as　carriers　to　deliver　a　candidate　AMP　on　titanium　surfaces　for　the　prevention　of　implant-associated　infections　is　assessed.　The　broad-spectrum　GL13K　(GKIIKLKASLKLL-CONH2)　AMP　derived　from　human　parotid　secretory　protein　was　selected　and　immobilized　to　TNTs　using　a　simple　soaking　technique.　Field　emission　scanning　electron　microscope,　X-ray　diffraction,　Fourier　transform　infrared　spectroscopy,　and　liquid　chromatography-mass　spectrometry　analyses　confirmed　the　successful　immobilization　of　GL13K　to　anatase　TNTs.　The　drug-loaded　coatings　demonstrated　a　sustained　and　slow　drug　release　profile　in　vitro　and　eradicated　the　growth　of　Fusobacterium　nucleatum　and　Porphyromonas　gingivalis　within　5　days　of　culture,　as　assessed　by　disk-diffusion　assay.　The　GL13K-immobilized　TNT　(GL13K-TNT)　coating　demonstrated　greater　biocompatibility,　compared　with　a　coating　produced　by　incubating　TNTs　with　equimolar　concentrations　of　metronidazole.　GL13K-TNTs　produced　no　observable　cytotoxicity　to　preosteoblastic　cells　(MC3T3-E1).　The　coating　may　also　have　an　immune　regulatory　effect,　in　support　of　rapid　osseointegration　around　implants.　Therefore,　the　combination　of　TNTs　and　AMP　GL13K　may　achieve　simultaneous　antimicrobial　and　osteoconductive　activities.