Background:　In　stent　design　optimization,　the　functional　relationship　between　design　parameters　and　design　goals　is　nonlinear,　complex,　and　implicit　and　the　multi-objective　design　of　stents　involves　a　number　of　potentially　conflicting　performance　criteria.　Therefore　it　is　hard　and　time-consuming　to　find　the　optimal　design　of　stent　either　by　experiment　or　clinic　test.　Fortunately,　computational　methods　have　been　developed　to　the　point　whereby　optimization　and　simulation　tools　can　be　used　to　systematically　design　devices　in　a　realistic　time-scale.　The　aim　of　the　present　study　is　to　propose　an　adaptive　optimization　method　of　stent　design　to　improve　its　expansion　performance.　Methods:　Multi-objective　optimization　method　based　on　Kriging　surrogate　model　was　proposed　to　decrease　the　dogboning　effect　and　the　radial　elastic　recoil　of　stents　to　improve　stent　expansion　properties　and　thus　reduce　the　risk　of　vascular　in-stent　reste-nosis　injury.　Integrating　design　of　experiment　methods　and　Kriging　surrogate　model　were　employed　to　construct　the　relationship　between　measures　of　stent　dilation　performance　and　geometric　design　parameters.　Expected　improvement,　an　infilling　sampling　criterion,　was　employed　to　balance　local　and　global　search　with　the　aim　of　finding　the　global　optimal　design.　A　typical　diamond-shaped　coronary　stent-balloon　system　was　taken　as　an　example　to　test　the　effectiveness　of　the　optimization　method.　Finite　element　method　was　used　to　analyze　the　stent　expansion　of　each　design.　Results:　27　iterations　were　needed　to　obtain　the　optimal　solution.　The　absolute　values　of　the　dogboning　ratio　at　32　and　42　ms　were　reduced　by　94.21　and　89.43%,　respectively.　The　dogboning　effect　was　almost　eliminated　after　optimization.　The　average　of　elastic　recoil　was　reduced　by　15.17%.　Conclusion:　This　article　presents　FEM　based　multi-objective　optimization　method　combining　with　the　Kriging　surrogate　model　to　decrease　both　the　dogboning　effect　and　radial　elastic　recoil　of　stents.　The　numerical　results　prove　that　the　proposed　optimization　method　effectively　decreased　both　the　dogboning　effect　and　radial　elastic　recoil　of　stent.　Further　investigations　containing　more　design　goals　and　more　effective　multidisciplinary　design　optimization　method　are　warranted.