Background:　Sequential　and　single　grafting　are　two　surgical　procedures　of　coronary　artery　bypass　grafting.　However,　it　remains　unclear　if　the　sequential　graft　can　be　used　between　the　right　and　left　coronary　artery　system.　The　purpose　of　this　paper　is　to　clarify　the　possibility　of　right　coronary　artery　system　anastomosis　to　left　coronary　system.　Methods:　A　patient-specific　3D　model　was　first　reconstructed　based　on　coronary　computed　tomography　angiography　(CCTA)　images.　Two　different　grafts,　the　normal　multi-graft　(Model　1)　and　the　novel　multi-graft　(Model　2),　were　then　implemented　on　this　patient-specific　model　using　virtual　surgery　techniques.　In　Model　1,　the　single　graft　was　anastomosed　to　right　coronary　artery　(RCA)　and　the　sequential　graft　was　adopted　to　anastomose　left　anterior　descending　(LAD)　and　left　circumflex　artery　(LCX).　While　in　Model　2,　the　single　graft　was　anastomosed　to　LAD　and　the　sequential　graft　was　adopted　to　anastomose　RCA　and　LCX.　A　zero-dimensional/three-dimensional　(0D/3D)　coupling　method　was　used　to　realize　the　multi-scale　simulation　of　both　the　pre-operative　and　two　post-operative　models.　Results:　Flow　rates　in　the　coronary　artery　and　grafts　were　obtained.　The　hemodynamic　parameters　were　also　showed,　including　wall　shear　stress　(WSS)　and　oscillatory　shear　index　(OSI).　The　area　of　low　WSS　and　OSI　in　Model　1　was　much　less　than　that　in　Model　2.　Conclusions:　Model　1　shows　optimistic　hemodynamic　modifications　which　may　enhance　the　long-term　patency　of　grafts.　The　anterior　segments　of　sequential　graft　have　better　long-term　patency　than　the　posterior　segments.　With　rational　spatial　position　of　the　heart　vessels,　the　last　anastomosis　of　sequential　graft　should　be　connected　to　the　main　branch.