Background:　PM2.5　is　an　important　factor　to　affect　the　patients　with　respiratory　and　cardiovascular　diseases.　Clinical　studies　have　found　that　the　morbidity　and　mortality　of　patients　with　heart　failure　(HF)　have　a　close　relationship　with　the　movement　and　deposition　state　of　PM2.5.　One　reason　is　that　the　breathing　pattern　of　patients　with　HF　has　obvious　difference　with　healthy　people,　however　the　effect　caused　by　these　differences　on　the　distribution　regularity　of　PM2.5　in　the　respiratory　tract　is　still　unclear.　Hence,　a　computational　fluid　dynamics　simulation　was　conducted　to　clarify　the　aerodynamic　effect　of　breathing　pattern　of　patients　with　HF　on　respiratory　system.　Methods:　Ideal　upper　respiratory　tract　geometric　model　was　established　based　on　standardized　aerosol　research　laboratory　of　Alberta　and　Weibel　A　dimension.　The　discrete　phase　method　is　used　to　calculate　the　movement　of　the　airflow　and　particles.　The　flow　rate　were　chosen　as　the　inlet　boundary　conditions,　and　the　outlets　are　set　at　a　constant　pressure.　The　rate　of　particle　deposition,　distribution　location,　wall　pressure,　flow　velocity　and　wall　shear　stress　are　obtained,　and　compared　to　the　normal　control.　Results:　The　results　demonstrated　that　the　rate　of　escaped　particles　in　every　bronchial　outlet　of　the　patients　with　HF　was　more　than　the　normal　controls,　meanwhile　the　trapped　was　less　(1024　＜　1160).　There　was　higher　by　12.9%　possibility　that　the　PM2.5　entered　the　lungs　than　the　normal　control.　Conclusion:　The　aerodynamic　performances　of　HF　patients　are　different　from　normal　control.　Compared　to　the　normal　control,　under　similar　environment,　there　is　higher　possibility　of　PM2.5　moving　into　lungs,　and　these　particles　could　affect　the　function　of　the　respiratory　system,　resulting　in　the　deterioration　of　the　state　of　cardiovascular　system.　In　short,　it＇s　necessary　to　pay　more　attention　to　the　living　environment　of　HF　patients,　to　reduce　the　content　of　PM2.5　particles　in　the　air,　and　reduce　the　damage　of　PM2.5　particles　caused　by　breathing　patterns.