The　scope　of　a　single　regional　indoor　positioning　network　is　often　restricted　to　its　main　anchor　communication　range　and　more　susceptible　to　obstacles.　Multiple　main　anchors　can　be　the　basis　of　an　indoor　positioning　network＇s　extensibility　and　can　adapt　to　the　complex　communication　environment.　In　this　article,　a　novel　TIME-DRIVEN　opportunistic　routing　protocol　with　intelligent　response　is　proposed.　First,　an　extendable　ultra-wideband　positioning　system　is　modeled.　In　two　or　more　communication　cells,　anchors　can　act　as　a　main　or　slave　anchor　in　different　areas,　respectively,　and　a　forward　clock　check　package　from　the　initial　district　to　its　surrounding　area.　They　can　also　achieve　the　clock　synchronization　of　the　entire　network.　In　this　model,　the　anchors　will　be　divided　into　different　sizes　of　clusters,　and　the　main　anchor　is　elected　according　to　the　broadcast　time.　Furthermore,　the　relay　anchor　will　be　intelligently　selected　according　to　the　opportunistic　probability　based　on　the　received　signal　strength　indicator.　Finally,　experiments　are　conducted　to　verify　the　performance　of　the　method.