A　facile　one-pot　method　was　used　to　prepare　C-18-bonded　ethyl-bridged　organic-inorganic　hybrid　silica　via　the　co-hydrolysis　and　condensation　of　1,2-bis(triethoxysilyl)ethane　(BTESE)　and　octadecyltriethoxysilane　(ODTES)　under　basic　condition.　The　pore　structure,　chemical　composition　and　liquid　chromatographic　performance　of　the　obtained　materials　were　investigated.　The　sample　MSS-0.08,　prepared　with　an　ODTES/BTESE　mole　ratio　of　0.08,　exhibits　a　desirable　mesoporous　structure　with　a　surface　area　of　352.82　m(2)　g(-1),　a　pore　volume　of　0.21　cm(3)　g(-1)　and　an　average　pore　size　of　3.72　nm　and　shows　a　hydrophobic　property　with　a　water　contact　angle　of　139.8　degrees　+/-　0.1　degrees.　When　used　as　stationary　phase　for　high　performance　liquid　chromatography　(HPLC),　MSS-0.08　realizes　a　baseline　separation　for　a　mixture　of　uracil,　pyridine,　phenol,　1-naphthylamine　and　naphthalene　and　exhibits　a　high　degree　of　resistance　to　alkali　at　elevated　temperature.　(C)　2016　Elsevier　Inc.　All　rights　reserved.