Sequential　graft　was　used　frequently　in　clinical　studies.　In　this　study,　the　hemodynamic　effect　of　one　kind　of　sequential　graft　in　two　different　conditions　of　the　lesion　was　discussed　and　some　recommendations　on　the　surgical　procedures　were　made.　A　patient-specific　three-dimensional　(3D)　model　of　left　anterior　descending　artery　(LAD)　was　reconstructed.　A　moderate　stenosis　exist　in　the　trunk　of　LAD　between　the　first　and　the　second　diagonal　branch　(D1　and　D2).　Another　3D　model　without　stenosis　was　also　reconstructed　based　on　the　patient-specific　model.　Sequential　graft　and　single　graft　were　applied　on　these　two　3D　model.　Thus　four　3D　models　were　built　so　that　the　hemodynamic　effect　of　sequential　graft　can　be　discussed.　The　zero-dimensional　(0D)/3D　coupling　method　was　used　to　perform　the　numerical　simulation　by　coupling　the　3D　artery　model　with　a　0D　lumped　parameter　model　of　the　cardiovascular　system.　The　flow　rates　in　the　branches　of　LAD　and　the　graft　flow　were　calculated　and　illustrated　in　this　paper.　The　wall　shear　stress　(WSS)　and　oscillatory　shear　index　(OSI)　were　also　calculated　and　depicted.　If　the　native　LAD　is　stenosis,　sequential　graft　should　be　applied　for　the　short-term　outcomes.　Moreover,　the　long-term　patency　of　the　sequential　graft　applied　on　the　stenosis　LAD　is　good.　The　long-term　patency　of　the　single　graft　was　bad.　But　the　short-term　outcomes　are　almost　the　same　when　LAD　is　not　stenosis.　If　no　stenosis　exist　in　the　native　LAD,　a　graft　with　smaller　diameter　should　be　applied　to　improve　the　long-term　patency.