Bimetallic　Au-Pd　alloy　nanoparticles　(NPs)　dispersed　on　nanohybrid　three-dimensionally　ordered　macro　porous　(3DOM)　La0.6Sr0.4MnO3　(LSMO)　perovskite　catalysts　were　fabricated　via　the　L-lysine-mediated　colloidal　crystalt-emplating　and　reduction　routes.　The　obtained　AuPd/3DOM　LSMO　samples　possess　a　nanovoid-like　3DOM　construction　with　well-dispersed　Au-Pd　alloy　NPs　(2.05-2.35　nm　in　size)　on　the　internal　walls　of　the　macropores.　The　Au-Pd　alloy　presence　favored　catalytic　activity　for　methane　combustion.　The　3DOM　LSMO　support　exhibits　three　key　attributes:　(i)　a　large　surface　area　(32.0-33.8　m(2)/g)　which　aids　high　dispersion　of　the　noble　metal　NPs　on　the　support　surface;　(ii)　abundant　Bronsted　acid　sites　which　facilitate　reactant　adsorption　and　activation;　and　(iii)　thermal　stability.　AuPd/3DOM　LSMO　has　been　synthesized　with　beneficial　properties,　including　a　richness　of　adsorbed　oxygen　species,　increased　oxidized　noble　metal　species,　low-temperature　reducibility,　and　strong　noble　metal-3DOM　LSMO　interaction,　all　contributing　to　provide　enhanced　activity　and　a　structure　with　high　thermal　and　hydrothermal　stability.　In　situ　diffuse　reflectance　infrared　Fourier　transform　spectroscopy　studies　revealed　that　including　Au　in　the　bimetallic　system　accelerated　the　reaction　rate　and　altered　the　reaction　pathway　for　methane　oxidation　by　enriching　the　adsorbed　oxygen　species　and　decreasing　the　bonding　strength　between　the　reaction　intermediates　and　the　Pd　atoms.