Although　a　growing　number　of　patients　undergo　LVAD　implantation　for　heart　failure　treatment,　thrombi　are　still　the　devastating　complication　for　patients　who　used　LVAD.　LVAD　outflow　cannula　location　and　thrombi　generation　sources　were　hypothesized　to　affect　the　thrombi　distribution　in　the　aorta.　To　test　this　hypothesis,　numerical　studies　were　conducted　by　using　computational　fluid　dynamic　(CFD)　theory.　Two　anastomotic　configurations,　in　which　the　LVAD　outflow　cannula　is　anastomosed　to　the　anterior　and　lateral　ascending　aortic　wall　(named　as　anterior　configurations　and　lateral　configurations,　respectively),　are　designed.　The　particles,　whose　sized　are　same　as　those　of　thrombi,　are　released　at　the　LVAD　output　cannula　and　the　aortic　valve　(named　as　thrombi(P)　and　thrombi(L),　respectively)　to　calculate　the　distribution　of　thrombi.　The　simulation　results　demonstrate　that　the　thrombi　distribution　in　the　aorta　is　significantly　affected　by　the　LVAD　outflow　cannula　location.　In　anterior　configuration,　the　thrombi　probability　of　entering　into　the　three　branches　is　23.60%,　while　that　in　lateral　configuration　is　36.68%.　Similarly,　in　anterior　configuration,　the　thrombi　probabilities　of　entering　into　brachiocephalic　artery,　left　common　carotid　artery　and　left　subclavian　artery,　is　8.51%,　9.64%,　5.45%,　respectively,　while　that　in　lateral　configuration　it　is　11.39%,　3.09%,　22.20%　respectively.　Moreover,　the　origins　of　thrombi　could　affect　their　distributions　in　the　aorta.　In　anterior　configuration,　the　thrombi(P)　has　a　lower　probability　to　enter　into　the　three　branches　than　thrombi(L)　(12%　vs.　25%).　In　contrast,　in　lateral　configuration,　the　thrombi(P)　has　a　higher　probability　to　enter　into　the　three　branches　than　thrombi(L)　(47%　vs.　35%).　In　brief,　the　LVAD　outflow　cannula　location　significantly　affects　the　distribution　of　thrombi　in　the　aorta.　Thus,　in　the　clinical　practice,　the　selection　of　outflow　location　of　LVAD　and　the　risk　of　thrombi　formed　in　the　left　ventricle　should　be　paid　more　attention　than　before.　(C)　2016　Elsevier　Ireland　Ltd.　All　rights　reserved.