Endovascular　surgery　has　become　one　of　the　main　methods　for　treatment　of　intracranial　arterial　stenosis.　Its　safety　and　efficacy　has　been　greatly　improved.　However,　in-stent　restenosis　(ISR)　remains　a　major　problem　challenging　interventional　treatment.　In　this　paper,　the　formation　of　ISR　at　the　proximal　end　of　stent　was　concerned　from　the　aspects　of　the　effect　of　bifurcation　angle.　Five　realistic　models　with　different　bifurcation　angle　(44.49A　degrees,　74.72A　degrees,　80.53A　degrees,　86.10A　degrees　and　95.37A　degrees)　were　built　by　using　Mimics.　Computational　fluid　dynamics　was　used　to　analyze　the　influence　of　vertebral　artery　bifurcation　angle　on　the　ISR.　The　area　of　low　wall　shear　stress　(WSS,　＜　1.5　Pa)　at　the　proximal　end　of　vertebral　artery　extracted　at　the　systole　in　the　five　models　were　1.05,　1.08,　3.90,　2.98　and　1.05e-4　m(2)　respectively.　The　area　of　low　WSS　extracted　at　the　diastole　were　2.17,　3.26,　2.43,　2.66　and　2.89e-4　m(2)　respectively.　Moreover,　the　time-averaged　WSS　of　the　five　models　were　4.19,　3.78,　5.01,　3.78　and　4.15　Pa　respectively.　Overall,　with　the　increase　of　bifurcation　angle,　the　area　of　lesion　is　prone　to　increase:　the　contact　of　blood　particles　with　the　luminal　surface　will　be　prolonged.　The　area　of　low　WSS　in　the　model　with　the　bifurcation　angle　of　74.72A　degrees　is　particularly　high　and　this　model　is　perhaps　the　most　prone　to　restenosis.