The　dissociation　process　of　gas　hydrates　is　also　the　discharging　process　of　the　gas　hydrate　cool　storage　system.　In　order　to　reduce　the　entropy　generation　rate　of　the　gas　hydrate　dissociation　process,　this　paper　takes　the　entropy　generation　minimization　as　the　optimization　objective　to　perform　thermodynamic　optimization　for　the　related　process.　By　establishing　thermodynamic　optimization　model　of　the　gas　hydrate　dissolution　process　based　on　entropy　generation　analysis,　both　the　optimal　control　strategy　and　the　optimal　heating　rate　of　the　gas　hydrate　dissolution　process　are　determined.　The　entropy　generation　rate　related　to　the　optimal　heating　rate　decreases　by　7.5%　compared　with　normal　situation.　The　research　results　can　provide　important　guidelines　for　optimal　design　and　operation　of　the　dissolution　process　of　gas　hydrates　related　to　the　gas　hydrate　cool　storage　system.　(C)　2016　Elsevier　Ltd.　All　rights　reserved.