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作者:

Li, Mi (Li, Mi.) (学者:栗觅) | Lu, Shengfu (Lu, Shengfu.) | Wang, Gang (Wang, Gang.) | Feng, Lei (Feng, Lei.) | Fu, Bingbing (Fu, Bingbing.) | Zhong, Ning (Zhong, Ning.)

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摘要:

Objective To explore working memory and the ability to process different emotional stimuli in patients with first-onset and untreated minor (mild or moderate) depression. Methods Patients with first-onset and previously untreated minor depression, and healthy controls, were enrolled. Using a modified Sternberg working memory paradigm to investigate the combined effects of emotional stimuli with working memory, participants were exposed to experimental stimuli comprising pictures that represented positive, neutral and negative emotions. Working memory ability was measured using reaction time and accuracy, and emotion-processing ability was measured using pupil diameter. Results Out of 36 participants (18 patients with minor depression and 18 controls), there were no statistically significant between-group differences in response time and accuracy. Positive stimuli evoked changes in pupil diameter that were significantly smaller in patients with minor depression versus controls, but changes in pupil diameter evoked by negative stimuli were not significantly different between the two groups. Conclusions Healthy subjects showed a stronger emotional response to positive emotional stimuli than patients with first onset and previously untreated minor depression, but there were no differences in response to negative emotions. There were no statistically significant between-group differences in terms of speed of cognitive response, but this may have been due to the relatively small samples sizes assessed. Studies with larger sample populations are required to further investigate these results.

关键词:

Depression emotion eye movement pupil diameter working memory

作者机构:

  • [ 1 ] [Li, Mi]Beijing Univ Technol, Int WIC Inst, Ping Le Yuan 100, Beijing 100124, Peoples R China
  • [ 2 ] [Lu, Shengfu]Beijing Univ Technol, Int WIC Inst, Ping Le Yuan 100, Beijing 100124, Peoples R China
  • [ 3 ] [Zhong, Ning]Beijing Univ Technol, Int WIC Inst, Ping Le Yuan 100, Beijing 100124, Peoples R China
  • [ 4 ] [Li, Mi]Beijing Int Collaborat Base Brain Informat & Wisd, Beijing, Peoples R China
  • [ 5 ] [Lu, Shengfu]Beijing Int Collaborat Base Brain Informat & Wisd, Beijing, Peoples R China
  • [ 6 ] [Zhong, Ning]Beijing Int Collaborat Base Brain Informat & Wisd, Beijing, Peoples R China
  • [ 7 ] [Li, Mi]Beijing Key Lab MRI & Brain Informat, Beijing, Peoples R China
  • [ 8 ] [Lu, Shengfu]Beijing Key Lab MRI & Brain Informat, Beijing, Peoples R China
  • [ 9 ] [Zhong, Ning]Beijing Key Lab MRI & Brain Informat, Beijing, Peoples R China
  • [ 10 ] [Wang, Gang]Capital Med Univ, Beijing Anding Hosp, Mood Disorders Ctr, Beijing, Peoples R China
  • [ 11 ] [Feng, Lei]Capital Med Univ, Beijing Anding Hosp, Mood Disorders Ctr, Beijing, Peoples R China
  • [ 12 ] [Fu, Bingbing]Capital Med Univ, Beijing Anding Hosp, Mood Disorders Ctr, Beijing, Peoples R China
  • [ 13 ] [Wang, Gang]Capital Med Univ, Beijing Anding Hosp, China Clin Res Ctr Mental Disorders, Beijing, Peoples R China
  • [ 14 ] [Feng, Lei]Capital Med Univ, Beijing Anding Hosp, China Clin Res Ctr Mental Disorders, Beijing, Peoples R China
  • [ 15 ] [Fu, Bingbing]Capital Med Univ, Beijing Anding Hosp, China Clin Res Ctr Mental Disorders, Beijing, Peoples R China
  • [ 16 ] [Wang, Gang]Beijing Inst Brain Disorders, Ctr Depress, Beijing, Peoples R China
  • [ 17 ] [Feng, Lei]Beijing Key Lab Mental Disorders, Beijing, Peoples R China
  • [ 18 ] [Zhong, Ning]Maebashi Inst Technol, Dept Life Sci & Informat, Maebashi, Gunma, Japan

通讯作者信息:

  • [Lu, Shengfu]Beijing Univ Technol, Int WIC Inst, Ping Le Yuan 100, Beijing 100124, Peoples R China

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来源 :

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

ISSN: 0300-0605

年份: 2016

期: 3

卷: 44

页码: 529-541

1 . 6 0 0

JCR@2022

ESI学科: CLINICAL MEDICINE;

ESI高被引阀值:128

中科院分区:4

被引次数:

WoS核心集被引频次: 14

SCOPUS被引频次: 14

ESI高被引论文在榜: 0 展开所有

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中文被引频次:

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