The　magnetic　mesoporous　SiO2/Fe3O4　hollow　microspheres,　which　have　a　unique　network-like　shell　constructed　with　magnetic　Fe3O4　nanorods　and　mesoporous　SiO2,　were　successfully　prepared　by　the　co-condensation　of　tetraethoxysilane　in　the　presence　of　cetyltrimethylammonium　bromide　and　1,3,5-triisopropylbenzene.　The　composite　microspheres　were　utilized　as　supports　for　laccase　immobilization.　The　composite　microsphere　has　high　surface　area　(772　m(2)　g(-1))　and　large　pore　volume　(0.83　cm(3)　g(-1)).　The　obtained　microspheres　exhibit　relatively　high　saturated　magnetization　(13.6　emu　g(-1)).　The　composite　mesoporous　microspheres　used　to　immobilize　laccase　as　support　have　a　notable　laccase　immobilization　(689　mg　g(-1))　for　per　gram　pure　mesoporous　SiO2　in　the　composite　microspheres,　which　is　much　larger　than　those　reported　in　the　literature.　The　activity　of　immobilized　laccase　has　good　pH　stability　and　thermal　stability.　It　is　further　demonstrated　that　the　immobilized　laccase　exhibited　a　good　catalytic　performance　when　they　were　used　to　react　with　the　2,4-dichlorophenol　solution.　The　degradation　rate　and　removal　rate　of　the　2,4-dichlorophenol　is　52.31　and　81.64　%,　respectively.