Working　accuracy　and　service　life　of　large　structural　parts　such　as　lathe　beds,　columns,　etc.　of　a　heavy-duty　machine　tool　with　large　self-weight　is　directly　influenced　by　the　foundation-soil　system.　Therefore,　simulation　of　the　interaction　of　the　heavy-duty　machine　tool　and　its　foundation-soil　system　is　a　key　technological　requirement　from　a　manufacturing　perspective.　However,　owing　to　the　size　of　the　structural　parts　of　most　heavy-duty　machine　tools,　and　the　complex　and　oversized　structure　of　their　foundation-soil　system,　typical　simulation　environments　fail　to　meet　the　computational　requirements.　With　an　aim　to　carry　out　simulations　and　meet　the　computational　demand　for　the　interaction　of　heavy-duty　machine　tools　and　their　foundation-soil　system;　a　constitutive　model　with　a　transversely　isotropic　composite　material　(the　reinforced　concrete　foundation)　was　developed　to　reduce　computation　load.　Then,　based　on　fractal　theory,　equations　for　calculating　stiffness　of　the　joint　surface　and　damping　matrix　were　deduced　to　overcome　common　technical　difficulty　facing　the　heavy-duty　machine　tool　industry.　Meanwhile,　establishing　a　finite　element　model　(FEM)　framework　in　a　cloud-computing　environment,　rapid　solution　of　the　FE　model　for　heavy-duty　machine　tool　foundation-soil　system　interactions　was　realized.　Finally,　a　comparison　of　experimental　results　can　be　used　to　validate　accuracy　of　the　analysis.　Furthermore,　cloud-computing　simulation　of　a　heavy-duty　machine　tool　foundation-soil　system　was　used　to　evaluate　efficacy　of　different　types　of　isolation　trenches.　The　results　provide　a　basis　for　the　construction　of　the　foundations　of　a　heavy-duty　machine　tool　and　the　selection　of　an　optimisation　scheme.