Two　new　metal-organic　frameworks　(MOFs),　[Cu-2(H2O)(2)(BCPIA)]　(BUT-20)　and　(Me2NH2)[In(BCPIA)]　(BUT-21)　were　designed　and　synthesized　through　the　solvothermal　reaction　between　a　newly　created　desymmetric　4-connected　ligand,　5-(2,6-bis(4-carboxyphenyl)pyridin-4-yl)isophthalic　acid　(H(4)BCPIA)　and　Cu(NO3)(2)center　dot　2.5H(2)O　or　In(NO3)(3)center　dot　5H(2)O,　respectively,　and　characterized　by　single-crystal　and　powder　Xray　diffraction,　thermogravimetric　analysis,　infrared　spectroscopy,　and　elemental　analysis.　The　two　MOFs　have　three-dimensional　structures,　in　which　both　the　BCPIA(4-)　ligand　and　metal-containing　entities,　Cu-2(COO)(4)(H2O)(2)　and　In(COO)(4)　act　as　4-connected　nodes.　However,　different　linkage　configurations　of　the　two　metal-containing　nodes,　quadrilateral　Cu-2(COO)(4)(H2O)(2)　and　tetrahedral　In(COO)(4),　lead　to　distinct　structural　networks　of　BUT-20　and　-21,　with　Nbo　and　Unc　topologies,　respectively.　(C)　2016　Chinese　Chemical　Society　and　Institute　of　Materia　Medica,　Chinese　Academy　of　Medical　Sciences.　Published　by　Elsevier　B.V.　All　rights　reserved.