Vanadium　oxide　supported　on　MSU-1,　with　VOx　loading　ranging　from　2.5　to　17.5　wt.　%,　was　developed　as　a　highly　active　catalyst　in　dehydrogenation　of　isobutane　with　CO2.　The　obtained　catalysts　of　VOx/MSU-1　were　characterized　by　X-ray　diffraction　(XRD),　N-2　adsorption-desorption,　and　H-2-temperature　programmed　reduction　(H-2-TPR)　methods　and　the　results　showed　that　the　large　surface　area　of　MSU-1　was　favorable　for　the　dispersion　of　VOx　species　and　the　optimal　loading　of　VOx　was　12.0　wt.　%.　Meanwhile,　the　catalytic　activity　of　VOx/MSU-1　was　investigated,　and　VOx/MSU-1　with　12.0　wt.　%　VOx　content　was　found　to　be　the　best　one,　with　the　conversion　of　isobutane　(58.8%)　and　the　selectivity　of　isobutene　(78.5%)　under　the　optimal　reaction　conditions.　In　contrast　with　the　reaction　in　the　absence　of　CO2,　the　presence　of　CO2　in　the　reaction　stream　could　obviously　enhance　the　isobutane　dehydrogenation,　which　raised　the　conversion　of　reaction　and　the　stability　of　VOx/MSU-1.