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作者:

Wu, Mixia (Wu, Mixia.) | Zhang, Dianchen (Zhang, Dianchen.) | Liu, Aiyi (Liu, Aiyi.)

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摘要:

New biomarkers continue to be developed for the purpose of diagnosis, and their diagnostic performances are typically compared with an existing reference biomarker used for the same purpose. Considerable amounts of research have focused on receiver operating characteristic curves analysis when the reference biomarker is dichotomous. In the situation where the reference biomarker is measured on a continuous scale and dichotomization is not practically appealing, an index was proposed in the literature to measure the accuracy of a continuous biomarker, which is essentially a linear function of the popular Kendall's tau. We consider the issue of estimating such an accuracy index when the continuous reference biomarker is measured with errors. We first investigate the impact of measurement errors on the accuracy index, and then propose methods to correct for the bias due to measurement errors. Simulation results show the effectiveness of the proposed estimator in reducing biases. The methods are exemplified with hemoglobin A1c measurements obtained from both the central lab and a local lab to evaluate the accuracy of the mean data obtained from the metered blood glucose monitoring against the centrally measured hemoglobin A1c from a behavioral intervention study for families of youth with type 1 diabetes.

关键词:

Bias diagnostic accuracy Kendall's tau measurement error reliability coefficient

作者机构:

  • [ 1 ] [Wu, Mixia]Beijing Univ Technol, Coll Appl Sci, Beijing, Peoples R China
  • [ 2 ] [Zhang, Dianchen]Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Biostat & Bioinformat Branch, Bethesda, MD USA
  • [ 3 ] [Liu, Aiyi]Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Biostat & Bioinformat Branch, Bethesda, MD USA

通讯作者信息:

  • [Liu, Aiyi]Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Biostat & Bioinformat Branch, Bethesda, MD USA;;[Liu, Aiyi]Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Biostat & Bioinformat Branch, 6710B Rockledge Dr,Room 3230, Bethesda, MD 20817 USA

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来源 :

JOURNAL OF BIOPHARMACEUTICAL STATISTICS

ISSN: 1054-3406

年份: 2016

期: 6

卷: 26

页码: 1111-1117

1 . 1 0 0

JCR@2022

ESI学科: PHARMACOLOGY & TOXICOLOGY;

ESI高被引阀值:104

中科院分区:4

被引次数:

WoS核心集被引频次: 2

SCOPUS被引频次: 1

ESI高被引论文在榜: 0 展开所有

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中文被引频次:

近30日浏览量: 2

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