A　single-chamber　and　membrane-less　microbial　fuel　cell　(MFC)　with　an　air　cathode　is　successfully　used　to　degrade　minocycline　and　produce　electricity　synchronously　using　glucose-minocycline　sodium　mixtures　as　fuel.　Results　show　that,　compared　with　traditional　anaerobic　reactors,　the　removal　of　minocycline　in　the　MFC　increased　by　67%.　Compared　with　the　dextrose　broth,　the　critical　amount　of　minocycline　that　is　conducive　to　producing　electricity　in　the　MFC　was　2　mg/L.　Experimental　results　also　showed　that　when　the　inlet　minocycline　concentration　was　2　mg/L,　the　HRT　was　24　h,　the　pH　was　7.0　and　the　phosphate　buffered　saline　concentration　was　100　mmol/L,　the　MFC　had　the　highest　removal　of　minocycline　and　the　best　electricity-generating　performance.　The　removal　of　minocycline　was　84.3%　and　the　removal　of　COD　was　88.9%.　Furthermore,　the　MFC　had　a　stable　voltage　of　538　mV,　an　internal　resistance　of　160.3　n　and　a　maximum　power　density　of　371.1　mW/m(2).