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作者:

Sun Guohui (Sun Guohui.) | Zhao Lijiao (Zhao Lijiao.) (学者:赵丽娇) | Zhong Rugang (Zhong Rugang.) (学者:钟儒刚)

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Scopus SCIE

摘要:

DNA interstrand crosslinks (ICLs) can be induced by numerous endogenous and exogenous chemical agents with the capacity of covalently binding to two base sites in the two strands of the DNA duplex. A series of normal DNA metabolism processes are affected by ICLs. For example, DNA replication and transcription are interfered during cell division, which is fatal to cell survival. In cancer cells, the induction of ICLs is a significant target for cancer chemotherapies. However, the formation of ICLs in cancer cells can be weakened by the repair mechanisms of DNA damage, which results in resistance to chemotherapies. Therefore, it is necessary to develop highly effective ICL agents for the purpose of achieving good chemotherapeutic effects. Furthermore, the combination of ICL agents with inhibitors of ICL repair is a promising strategy for the clinical treatment of cancer. This review summarizes the development of several types of ICL agents as chemotherapies over the past decades and the mechanisms underlying the repair of DNA ICLs. The potential of ICL repair inhibitors for combination therapy with ICL agents in cancer treatment is also discussed.

关键词:

Anticancer efficiency inhibitors cytotoxicity combination chemotherapy DNA interstrand crosslinks repair mechanism

作者机构:

  • [ 1 ] [Sun Guohui]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing Key Lab Environm & Viral Oncol, Beijing 100124, Peoples R China
  • [ 2 ] [Zhao Lijiao]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing Key Lab Environm & Viral Oncol, Beijing 100124, Peoples R China
  • [ 3 ] [Zhong Rugang]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing Key Lab Environm & Viral Oncol, Beijing 100124, Peoples R China

通讯作者信息:

  • 赵丽娇

    [Zhao Lijiao]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing Key Lab Environm & Viral Oncol, Beijing 100124, Peoples R China

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来源 :

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY

ISSN: 1871-5206

年份: 2016

期: 2

卷: 16

页码: 221-246

2 . 8 0 0

JCR@2022

ESI学科: PHARMACOLOGY & TOXICOLOGY;

ESI高被引阀值:169

中科院分区:3

被引次数:

WoS核心集被引频次: 17

SCOPUS被引频次: 20

ESI高被引论文在榜: 0 展开所有

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