We　report　a　novel　strategy　for　the　synthesis　of　magnetic-based　flower-like　silver　composite　microspheres　(Fe3O4@SiO2@Ag　microflowers)　with　a　highly　branched　shell　structure　through　a　sonochemical-assisted　method.　The　obtained　Fe3O4@SiO2@Ag　microflowers　possess　good　dispersity,　high　magnetic　responsiveness,　and　highly　reproducible　structures.　The　size　and　morphology　of　the　silver　petal　shell　of　these　microflowers　can　be　easily　controlled　by　varying　the　experimental　parameters.　The　silver　petal　provides　an　effectively　large　surface　area　for　forming　sufficient　plasmonic　hot　spots　and　capturing　target　molecules.　The　microscale　magnetic　core　endows　microflowers　with　superior　magnetic　nature　to　enrich　targeted　analytes　and　create　abundant　interparticle　hot　spots　through　magnetism-induced　aggregation.　Hence,　Fe3O4@SiO2@Ag　microflowers　could　be　a　versatile　SERS　substrate,　as　verified　by　the　detection　of　the　non-adsorbed　R6G　molecules　and　the　adsorbed　pesticide　thiram,　with　a　detection　limit　as　low　as　1　x　10(-14)　M　and　1　x　10(-11)　M,　respectively.　We　further　demonstrate　that　aptamer-functionalized　microflowers　can　easily　capture　S.　aureus　in　tap　water　and　significantly　enhance　their　SERS　signal.　Moreover,　the　microflowers　can　be　easily　recycled　because　of　the　intrinsic　magnetism　of　the　Fe3O4　cores,　which　indicate　a　new　route　in　eliminating　the　＂single-use＂　problem　of　traditional　SERS　substrates.　These　advantages　make　the　microflowers　powerful　SERS　probes　for　chemical　and　biological　analyses.