Multiple　geophysical　parameters　including　groundwater　level,　water　temperature,　water　radon,　crustal　deformation,　electromagnetic　waves　and　total　electron　contents　(TEC)　in　the　ionosphere,　are　examined　together　to　investigate　pre-earthquake　anomalous　phenomena　associated　with　the　Mw6.1　Ludian　earthquake　on　August　3,　2014.　Cross-parameter　comparison　eliminates　anomalies　that　are　detected　in　one　parameter　only　and　examine　earthquake-related　phenomena　in　various　fields,　simultaneously.　Retrieved　anomalies　show　that　abnormal　decreases　of　water　temperature　and　radon　concentration　related　to　anomalous　uplift　of　groundwater　levels　appeared　about　1-8　days　before　the　earthquake　even　without　contributions　from　rain.　Significant　step-like　changes　are　observed　from　data　recorded　by　strainmeters　on　July　31　and　are　consistent　with　water-related　anomalies　in　timing.　No　significant　anomalies　can　be　found　from　electromagnetic　data　through　the　preliminary　observation.　In　contrast,　TEC　appeared　positive　anomalies　1-3　days　before　the　Ludian　earthquake.　Although　causal　mechanisms　of　the　TEC　anomalies　from　stressed　rocks　are　not　fully　understood,　multiple-parameter　examination　can　increase　credibility　of　determination　regarding　pre-earthquake　phenomena.　(c)　Elsevier　Ltd.　All　rights　reserved.