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Author:

Wang, Jing (Wang, Jing.) | Liu, Shenquan (Liu, Shenquan.) | Wang, Hongchu (Wang, Hongchu.) | Ju, Niansheng (Ju, Niansheng.) | Zeng, Yanjun (Zeng, Yanjun.)

Indexed by:

Scopus SCIE

Abstract:

As the principal cell of the striatum, medium spiny neurons (MSNs) are closely associated with various motor dysfunctional diseases. In this paper, we describe an electric compartment model constructed in NEURON with a realistic morphology. Based on a 554-compartment computational model, we researched the influence of external current stimuli, different ions conductance, and the removal of partial dendrites on the physiological properties of the MSN. The main results are the following: (1) in the case of external current stimuli, various firing patterns appear in the MSN and the model produces a clear period-adding bifurcation phenomenon; (2) the effect of distinct types of ion channels vary and significant differences in discharge rhythm exist even among ion channels of the same type; (3) the closer the removed dendrite was to the soma, the larger the impact this had on the discharge pattern of the MSN.

Keyword:

Medium spiny neuron (MSN) The number of spikes per burst (NS) Interspike intervals (ISI) Discharge rhythm

Author Community:

  • [ 1 ] [Wang, Jing]South China Univ Technol, Sch Math, Guangzhou 510640, Guangdong, Peoples R China
  • [ 2 ] [Liu, Shenquan]South China Univ Technol, Sch Math, Guangzhou 510640, Guangdong, Peoples R China
  • [ 3 ] [Ju, Niansheng]South China Univ Technol, Sch Math, Guangzhou 510640, Guangdong, Peoples R China
  • [ 4 ] [Wang, Hongchu]South China Normal Univ, Sch Math Sci, Guangzhou 510631, Guangdong, Peoples R China
  • [ 5 ] [Zeng, Yanjun]Beijing Univ Technol, Ctr Biomed Engn, Beijing 100022, Peoples R China

Reprint Author's Address:

  • [Liu, Shenquan]South China Univ Technol, Sch Math, Guangzhou 510640, Guangdong, Peoples R China

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Source :

NEUROLOGICAL RESEARCH

ISSN: 0161-6412

Year: 2015

Issue: 12

Volume: 37

Page: 1074-1081

1 . 9 0 0

JCR@2022

ESI Discipline: NEUROSCIENCE & BEHAVIOR;

ESI HC Threshold:252

JCR Journal Grade:4

CAS Journal Grade:4

Cited Count:

WoS CC Cited Count: 1

SCOPUS Cited Count: 2

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 2

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